Efficacy of High-dose Chemotherapy and Autologous Stem Cell Transplantation in Patients with Relapsed Medulloblastoma: A Report on The Korean Society for Pediatric Neuro-Oncology (KSPNO)-S-053 Study
Journal of Korean Medical Science
; : 1160-1166, 2010.
Article
in En
| WPRIM
| ID: wpr-187253
Responsible library:
WPRO
ABSTRACT
The efficacy and toxicity of high-dose chemotherapy and autologous stem cell transplantation (HDCT/ASCT) were investigated for improving the outcomes of patients with relapsed medulloblastoma. A total of 15 patients with relapsed medulloblastoma were enrolled in the KSPNO-S-053 study from May 2005 to May 2007. All patients received approximately 4 cycles of salvage chemotherapy after relapse. Thirteen underwent HDCT/ASCT; CTE and CM regimen were employed for the first HDCT (HDCT1) and second HDCT (HDCT2), respectively, and 7 underwent HDCT2. One transplant related mortality (TRM) due to veno-occlusive disease (VOD) occurred during HDCT1 but HDCT2 was tolerable with no further TRM. The 3-yr overall survival probability and event-free survival rates +/-95% confidence intervals (CI) were 33.3+/-12.2% and 26.7% +/-11.4%, respectively. When analysis was confined to only patients who had a complete response (CR) or partial response (PR) prior to HDCT, the probability of 3-yr overall survival rates +/-95% CI was 40.0+/-15.5%. No patients with stable disease (SD) or progressive disease (PD) survived. Survival rates from protocol KSPNO-S-053 are encouraging and show that tumor status prior to HDCT/ASCT is an important factor to consider for improving survival rates of patients with relapsed medulloblastoma.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Transplantation, Autologous
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Cerebellar Neoplasms
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Salvage Therapy
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Combined Modality Therapy
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Hematopoietic Stem Cell Transplantation
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Disease-Free Survival
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Republic of Korea
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Medulloblastoma
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Neoplasm Recurrence, Local
Limits:
Adolescent
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Child
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Child, preschool
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Female
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Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2010
Type:
Article