Lamotrigine Augmentation in Patients with Treatment-Resistant Major Depressive Disorder: A Naturalistic Study / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 276-282, 2008.
Article
in Korean
| WPRIM
| ID: wpr-18727
ABSTRACT
OBJECTIVE:
Lamotrigine's possible efficacy in the treatment of depressive disorders has been suggested. This naturalistic study investigated clinical response to lamotrigine augmentation in patients with treatment-resistant depression. Characteristics of the lamotrigine-responders were also explored.METHODS:
Clinical data from 40 lamotrigine- treated patients with treatment-resistant unipolar depression were analyzed. The subjects were diagnosed with DSM-IV major depressive disorder and resistant to at least 2 antidepressants. Efficacy of lamotrigine treatment was measured by the changes in mean scores of the Clinical Global Impression Severity subscale (CGI-S), which were extracted from the prospective mood chart and structured interviews. Response was defined as a decrease of at least 2 or more from baseline on the CGI-S. Untoward effects associated with lamotrigine treatment were also assessed through medical records.RESULTS:
Significant reduction in the CGI-S mean score was observed from baseline through 8 week lamotrigine augmentation in 40 patients with treatment-resistant unipolar depression (t=5.7, df=39, p<.01), and the magnitude of treatment effect was large (r(effect size)=0.68). Drop-outs were mainly attributable to lamotrigine-associated rash (N=5). Greater rate of improvement was associated with responder group (N=14) compared to non-responder group (N=17) from week 3 onward.CONCLUSION:
The results of current study lend support to the potential benefit of lamotrigine augmentation in a subpopulation of patients with treatmentresistant unipolar depression. Continuation of lamotrigine add-on for more than 3 weeks may be needed to assess clinical outcome. Lamotrigine augmentation was generally well-tolerated. Large scale, double-blind studies are necessary to confirm its use as an augmentation agent.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Triazines
/
Medical Records
/
Double-Blind Method
/
Diagnostic and Statistical Manual of Mental Disorders
/
Depression
/
Depressive Disorder, Major
/
Depressive Disorder
/
Exanthema
/
Antidepressive Agents
Type of study:
Controlled clinical trial
/
Qualitative research
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Psychopharmacology
Year:
2008
Type:
Article
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