Effect of Etomidate on the Expressions of c-JUN and Heat Shock Protein 70 Induced by Kainic Acid in Rats / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 253-259, 2004.
Article
in Korean
| WPRIM
| ID: wpr-187324
ABSTRACT
BACKGROUND:
The present investigation was undertaken to evaluate the neuroprotective effect of etomidate against kainic acid (KA) induced neurotoxicity in rats by Western immunoblotting for heat shock protein 70 (HSP-70), c-JUN, and by acid-fuchsin histochemistry.METHODS:
Etomidate (20 mg/kg, i.p.) was administered in sequence, first being just one hour after KA (10 mg/kg, i.p.) injection, then three times one hour intervals. Neuronal damage in hippocampus was evaluated by using acid-fuchsin stain to detect cell death and HSP-70 and c-JUN induction as an index of cell injury at 3, 6, 24 and 48 h after the administration of KA.RESULTS:
Acid fuchsin positive neurons were increased in the CA1 and CA3 regions of the hippocampus after KA injection, but were significantly decreased by etomidate injection (P <0.01). Etomidate administration also significantly suppressed the KA-induced induction of c-JUN and HSP-70 in both regions of the rat hippocampus.CONCLUSIONS:
These results suggest that etomidate has a protective effect on hippocampal neurons against KA-induced neurotoxicity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rosaniline Dyes
/
Blotting, Western
/
Cell Death
/
Neuroprotective Agents
/
HSP70 Heat-Shock Proteins
/
Etomidate
/
Hot Temperature
/
Heat-Shock Proteins
/
Hippocampus
/
Kainic Acid
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2004
Type:
Article
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