Primary Hyperaldosteronism with Increased Plasma Renin Activity due to Secondary Hypertensive Renal Impairment / 대한내분비학회지
Journal of Korean Society of Endocrinology
;
: 433-438, 2003.
Article
in Korean
| WPRIM
| ID: wpr-187342
ABSTRACT
An increased plasma aldosterone concentration, with suppressed plasma renin activity (PRA), is an abnormal finding in primary hyperaldosteronism. A suppressed PRA is caused by aldosterone- dependent sodium retention and extracellular volume expansion. A case of primary hyperaldosteronism, due to adenoma, with increased PRA, was observed. An adrenalectomy and intraoperative renal biopsy was performed. In our patient, histologically proven renal arteriosclerosis was the probable cause of the escape of the PRA from the suppression by an aldosterone-producing adenoma. Normal blood pressure was not attained after the adrenalectomy. However, the blood pressure was then controlled by small doses of antihypertensive drug before resection of the tumor. In this case, the patient was treated with spironolactone, but the blood pressure was not correctly controlled. After the adrenalectomy, the blood pressure was well controlled with smaller dose of calcium channel blockers. So, an early adrenalectomy may be beneficial as soon as the diagnosis of an aldosterone-producing adenoma is confirmed, even in patients with hypertensive nephrosclerosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Arteriosclerosis
/
Sodium
/
Spironolactone
/
United Nations
/
Biopsy
/
Blood Pressure
/
Calcium Channel Blockers
/
Adenoma
/
Renin
Type of study:
Diagnostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of Korean Society of Endocrinology
Year:
2003
Type:
Article
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