Der p 1, Der p 2 and Der p 10 IgE Reactivities in Allergic Rhinitis Patients in Korea
Journal of Rhinology
; : 91-96, 2016.
Article
in Ko
| WPRIM
| ID: wpr-187447
Responsible library:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES: To evaluate IgE reactivity profiles to Der p 1, Der p 2, and Der p 10 in house dust mite (HDM) allergic rhinitis (AR) patients in Korea. Symptomatic and serologic changes after sublingual immunotherapy (SLIT) were analyzed according to IgE profiles. MATERIALS AND METHODS: Sixty AR patients diagnosed with an HDM allergy were tested for the presence of IgE antibodies against purified HDM allergen molecules (i.e., nDer p 1, rDer p 2, and rDer p 10) and native Dermatophagoides pteronyssinus (Dp) using ImmunoCAP 250®. Symptom scores and laboratory findings were analyzed after SLIT. RESULTS: Prevalence rates of IgE for Dp, Der p 1, Der p 2, and Der p 10 were 100%, 98.3%, 93.3%, and 8.3%, respectively. After one year of immunotherapy with SLITone○R (standardized to major allergens, but not Der p 10), symptom scores and laboratory findings improved in patients with and without Der p 10 IgE antibodies. CONCLUSION: In Korean AR patients, specific IgE antibodies to Der p 1 or Der p 2 are present in most Dp-allergic patients, while reactivity to Der p 10 is very low. Allergic symptoms improved in patients with Der p 10 IgE antibodies after SLIT.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Immunoglobulin E
/
Allergens
/
Prevalence
/
Pyroglyphidae
/
Dermatophagoides pteronyssinus
/
Antigens, Dermatophagoides
/
Sublingual Immunotherapy
/
Rhinitis, Allergic
/
Hypersensitivity
/
Immunotherapy
Type of study:
Prevalence_studies
Limits:
Humans
Country/Region as subject:
Asia
Language:
Ko
Journal:
Journal of Rhinology
Year:
2016
Type:
Article