Comparison of Amicus and CS-3000 Plus for the Collection of Peripheral Blood Stem Cells / 대한수혈학회지
Korean Journal of Blood Transfusion
;
: 39-47, 2006.
Article
in Korean
| WPRIM
| ID: wpr-187480
ABSTRACT
BACKGROUND:
The efficient collection of peripheral blood stem cells (PBSC) from donors who donate for allogeneic transplants as well as from patients undergoing autologous transplants is essential for a successful transplant. Recently, the Amicus cell separator and the associated MNC collection computer software program for PBSC collection were introduced in Korea.METHODS:
Two apheresis machines (Amicus, Baxter Healthcare; and CS-3000 plus, Baxter Healthcare) were compared retrospectively. A total number of 144 procedures were performed on 14 donors and 28 patients. The pre- and post-apheresis complete blood cell (CBC) counts and the number of hematopoietic progenitor cells (HPC) were determined in the peripheral blood from the subjects. The CBC, HPC, CD34+ cell counts and the level of colony-forming unit-granulocyte-macrophages (CFU-GM) were measured in the PBSC product collected from both machines.RESULTS:
Both machines collected a similar number of CD34+ cells from the donors and patients. On the other hand, the Amicus collected significantly more nucleated cells, MNCs, HPCs and CFU-GM in the patients with significantly less RBC contamination than those with CS-3000 plus. The decrease in the peripheral blood platelet counts in the donors and patients was more prominent after apheresis using the CS-3000 plus (117.00+/-42.75 x 10(3)/microliter, 61.22+/-43.62 x 10(3)/microliter) than Amicus (26.04+/-18.68 x 10(3)/microliter, 22.15+/-28.66 x 10(3)/microliter)(p<0.05).CONCLUSION:
PBSC collection can be performed successfully using CS-3000 plus and Amicus. Amicus is superior to CS-3000 plus in avoiding apheresis-induced thrombocytopenia, and is expected to prevent unnecessary platelet transfusion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Platelet Count
/
Stem Cells
/
Thrombocytopenia
/
Tissue Donors
/
Blood Cells
/
Blood Component Removal
/
Hematopoietic Stem Cells
/
Cell Count
/
Retrospective Studies
/
Platelet Transfusion
Type of study:
Observational study
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Blood Transfusion
Year:
2006
Type:
Article
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