Your browser doesn't support javascript.
loading
Changes in Adenosine Deaminase Activity in Patients with Type 2 Diabetes Mellitus and Effect of DPP-4 Inhibitor Treatment on ADA Activity
Diabetes & Metabolism Journal ; : 149-158, 2011.
Article in English | WPRIM | ID: wpr-187622
ABSTRACT

BACKGROUND:

Dipeptidyl peptidase 4 (DPP-4, also known as CD26) binds with adenosine deaminase (ADA) to activate T lymphocytes. Here, we investigated whether ADA activity is specifically affected by treatment with DPP-4 inhibitor (DPP4I) compared with other anti-diabetic agents.

METHODS:

Fasting ADA activity, in addition to various metabolic and biochemical parameters, were measured in 262 type 2 diabetes mellitus (T2DM) patients taking various anti-diabetic agents and in 46 non-diabetic control subjects.

RESULTS:

ADA activity was increased in T2DM patients compared with that in non-diabetic control subjects (mean+/-standard error, 23.1+/-0.6 U/L vs. 18.6+/-0.8 U/L; P9%) showed significantly increased ADA activity (21.1+/-0.8 U/L vs. 25.4+/-1.6 U/L; P<0.05). The effect of DPP4I on ADA activity in T2DM patients did not differ from those of other oral anti-diabetic agents or insulin. T2DM patients on metformin monotherapy showed a lower ADA activity (20.9+/-1.0 U/L vs. 28.1+/-2.8 U/L; P<0.05) compared with that of those on sulfonylurea monotherapy.

CONCLUSION:

Our results show that ADA activity is increased in T2DM patients compared to that in non-diabetic patients, is positively correlated with blood glucose level, and that DPP4I has no additional specific effect on ADA activity, except for a glycemic control- or HbA1c-dependent effect.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasma / Aspartate Aminotransferases / Blood Glucose / T-Lymphocytes / Adenosine / Adenosine Deaminase / Fasting / Dipeptidyl Peptidase 4 / Diabetes Mellitus, Type 2 / Alanine Transaminase Limits: Humans Language: English Journal: Diabetes & Metabolism Journal Year: 2011 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasma / Aspartate Aminotransferases / Blood Glucose / T-Lymphocytes / Adenosine / Adenosine Deaminase / Fasting / Dipeptidyl Peptidase 4 / Diabetes Mellitus, Type 2 / Alanine Transaminase Limits: Humans Language: English Journal: Diabetes & Metabolism Journal Year: 2011 Type: Article