18F-FDG PET/CT in the Clinical Assessment of Patients with Multiple Myeloma: A Pilot Study / 대한내과학회지
Korean Journal of Medicine
;
: 689-695, 2012.
Article
in Korean
| WPRIM
| ID: wpr-187690
ABSTRACT
BACKGROUND/AIMS:
This study investigated the clinical utility of positron emission tomography/computed tomography (PET/CT) for evaluating bone lesions in patients with multiple myeloma before therapy.METHODS:
Whole-spine and pelvic magnetic resonance imaging (MRI) and whole-body PET/CT were conducted in patients newly diagnosed with multiple myeloma before therapy. We compared the PET/CT and MRI results for the entire spine and pelvis, and the discordance rates were cross-analyzed with the clinical factors.RESULTS:
Ten patients were enrolled (median age 57.5 years). The majority were at an advanced stage, and IgG type multiple myeloma occurred in seven patients. All patients underwent PET/CT and 36 sites were checked on MRI. Approximately 69% of the patients had diffuse patterns, 8.3% had focal lesions, 5.6% had mixed lesions, and 16.7% had a normal pattern on MRI. The concordance rate of PET/CT compared with MRI was 83.3% (30 sites). The false-positive rate was 13.9% and the false-negative rate was 2.8%. No factor predicted the discordance between the PET/CT and MRI results.CONCLUSIONS:
A well-designed, large-scale study is warranted to confirm the accuracy of PET/CT for detecting bone lesions in these patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pelvis
/
Spine
/
Immunoglobulin G
/
Magnetic Resonance Imaging
/
Pilot Projects
/
Fluorodeoxyglucose F18
/
Electrons
/
Multiple Myeloma
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2012
Type:
Article
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