The Topical Effects of Antibiotics and Aprotinin in Experimental Pseudomonas Ketaititis
Journal of the Korean Ophthalmological Society
;
: 181-187, 1993.
Article
in Korean
| WPRIM
| ID: wpr-187757
ABSTRACT
The effects of the topically applied antibiotics and Aprotinin were evaluated in the experimentally induced pseudomonas aeruginosa keratitis in rabbits. 40 albino rabbits were used for this study and were divided into 8 groups according to the treatment protocols as follows Aprotinin 40u/ml, 1,OOOu/ml, 1O,000u/ml, antibiotics (Ciprofloxacin and Tobramycin), and antibiotics and Aprotinin combined-treated group. The drugs were instilled in the rabbits, cornea 6 times per day for 2 weeks. The clinical evaluation was performed using a hand-held slit lamp every day. For the histopathologic examination, we enucleated every samples at different time intervals and prepared specimens for light microscope. The results were Aprotinin-treated group showed progression of ulcer infiltrates regardless of its concentrations. There was a statistically significant difference between the antibiotics-treated group and the control group (p0.05). There was no clinical and histopathological differences in the rabbit cornea between ciprofloxacin and tobramycin treated group (p>0.05).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pseudomonas
/
Pseudomonas aeruginosa
/
Tobramycin
/
Ulcer
/
Ciprofloxacin
/
Clinical Protocols
/
Aprotinin
/
Cornea
/
Keratitis
/
Anti-Bacterial Agents
Type of study:
Practice guideline
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
1993
Type:
Article
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