Cytomegalovirus Ventriculoencephalitis after Unrelated Double Cord Blood Stem Cell Transplantation with an Alemtuzumab-containing Preparative Regimen for Philadelphia-positive Acute Lymphoblastic Leukemia
Journal of Korean Medical Science
;
: 630-633, 2010.
Article
in English
| WPRIM
| ID: wpr-188010
ABSTRACT
Despite the prophylaxis and preemptive strategies using potent antiviral agents, cytomegalovirus (CMV) remains a major infectious cause of morbidity and mortality in allogeneic stem cell transplantation (SCT) recipients. Delayed immune reconstitution after SCT, such as cord blood and T-cell depleted SCT with the use of alemtuzumab, has been associated with an increased frequency of CMV disease as well as CMV reactivation. CMV disease involving central nervous system is an unusual presentation in the setting of SCT. We report a case of CMV ventriculoencephalitis after unrelated double cord blood SCT with an alemtuzumab-containing preparative regimen for Philadelphia-positive acute lymphoblastic leukemia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Fatal Outcome
/
Cytomegalovirus Infections
/
Transplantation Conditioning
/
Cytomegalovirus
/
Cord Blood Stem Cell Transplantation
/
Encephalitis
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Antibodies, Monoclonal, Humanized
/
Antibodies, Monoclonal
/
Antibodies, Neoplasm
Limits:
Humans
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2010
Type:
Article
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