The Suppressive Effect of Evening Primrose Oil on Murine Contact Sensitivity
Annals of Dermatology
;
: 39-44, 1995.
Article
in English
| WPRIM
| ID: wpr-18833
ABSTRACT
BACKGROUND:
Evening primrose oil(EPO) is a rich source of cis-linoleic acid and gammalinolenic acid(GLA) and has been used as a therapeutic agent in various skin diseases such as atopic dermatitis.OBJECTIVE:
The purpose of this study was to evaluate the suppressive effect of EPO on murine contact sensitivity.METHODS:
BALB/c mice were divided into 3 groups, positive control, experimental and negative control groups the positive control group represents a group of mice which were sensitized and challenged with DNFB, the experimental group represents EPO-pretreated positive control group and the negative control group represents a group of mice which were challenged only. The changes of ear thickness were measured, and H & E staining and immunohistochemical staining for ICAM-1 expression of ear skin were performed to evaluate the histological changes of each group.RESULTS:
The Pretreatment of mice with EPO resulted in suppression of contact sensitivity by more than 82%. On H & E staining, only a mild inflammatory reaction was observed in the dermis. Also ICAM-1 expression of keratinocytes, the intensity of the staining was significantly decreased in the experimental group compared with positive group.CONCLUSIONS:
Our study indicates that EPO was able to suppress the induction of contact sensitivity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
Skin Diseases
/
Keratinocytes
/
Oenothera biennis
/
Intercellular Adhesion Molecule-1
/
Dermis
/
Dermatitis, Atopic
/
Dermatitis, Contact
/
Dinitrofluorobenzene
/
Ear
Type of study:
Diagnostic study
Limits:
Animals
Language:
English
Journal:
Annals of Dermatology
Year:
1995
Type:
Article
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