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The Suppressive Effect of Evening Primrose Oil on Murine Contact Sensitivity
Annals of Dermatology ; : 39-44, 1995.
Article in English | WPRIM | ID: wpr-18833
ABSTRACT

BACKGROUND:

Evening primrose oil(EPO) is a rich source of cis-linoleic acid and gammalinolenic acid(GLA) and has been used as a therapeutic agent in various skin diseases such as atopic dermatitis.

OBJECTIVE:

The purpose of this study was to evaluate the suppressive effect of EPO on murine contact sensitivity.

METHODS:

BALB/c mice were divided into 3 groups, positive control, experimental and negative control groups the positive control group represents a group of mice which were sensitized and challenged with DNFB, the experimental group represents EPO-pretreated positive control group and the negative control group represents a group of mice which were challenged only. The changes of ear thickness were measured, and H & E staining and immunohistochemical staining for ICAM-1 expression of ear skin were performed to evaluate the histological changes of each group.

RESULTS:

The Pretreatment of mice with EPO resulted in suppression of contact sensitivity by more than 82%. On H & E staining, only a mild inflammatory reaction was observed in the dermis. Also ICAM-1 expression of keratinocytes, the intensity of the staining was significantly decreased in the experimental group compared with positive group.

CONCLUSIONS:

Our study indicates that EPO was able to suppress the induction of contact sensitivity.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Skin / Skin Diseases / Keratinocytes / Oenothera biennis / Intercellular Adhesion Molecule-1 / Dermis / Dermatitis, Atopic / Dermatitis, Contact / Dinitrofluorobenzene / Ear Type of study: Diagnostic study Limits: Animals Language: English Journal: Annals of Dermatology Year: 1995 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Skin / Skin Diseases / Keratinocytes / Oenothera biennis / Intercellular Adhesion Molecule-1 / Dermis / Dermatitis, Atopic / Dermatitis, Contact / Dinitrofluorobenzene / Ear Type of study: Diagnostic study Limits: Animals Language: English Journal: Annals of Dermatology Year: 1995 Type: Article