Clinical Implications of Pneumococcal Serotypes: Invasive Disease Potential, Clinical Presentations, and Antibiotic Resistance
Journal of Korean Medical Science
;
: 4-15, 2013.
Article
in English
| WPRIM
| ID: wpr-188351
ABSTRACT
Streptococcus pneumoniae can asymptomatically colonize the nasopharynx and cause a diverse range of illnesses. This clinical spectrum from colonization to invasive pneumococcal disease (IPD) appears to depend on the pneumococcal capsular serotype rather than the genetic background. According to a literature review, serotypes 1, 4, 5, 7F, 8, 12F, 14, 18C, and 19A are more likely to cause IPD. Although serotypes 1 and 19A are the predominant causes of invasive pneumococcal pneumonia, serotype 14 remains one of the most common etiologic agents of non-bacteremic pneumonia in adults, even after 7-valent pneumococcal conjugate vaccine (PCV7) introduction. Serotypes 1, 3, and 19A pneumococci are likely to cause empyema and hemolytic uremic syndrome. Serotype 1 pneumococcal meningitis is prevalent in the African meningitis belt, with a high fatality rate. In contrast to the capsule type, genotype is more closely associated with antibiotic resistance. CC320/271 strains expressing serotype 19A are multidrug-resistant (MDR) and prevalent worldwide in the era of PCV7. Several clones of MDR serotype 6C pneumococci emerged, and a MDR 6D clone (ST282) has been identified in Korea. Since the pneumococcal epidemiology of capsule types varies geographically and temporally, a nationwide serosurveillance system is vital to establishing appropriate vaccination strategies for each country.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peritonitis
/
Pneumococcal Infections
/
Pneumonia, Pneumococcal
/
Streptococcus pneumoniae
/
Serotyping
/
Drug Resistance, Multiple, Bacterial
/
Empyema
/
Hemolytic-Uremic Syndrome
/
Meningitis
Limits:
Humans
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2013
Type:
Article
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