Risk Factors in Anticancer Chemotherapy Induced Thrombocytopenia Requiring Platelet Transfusion / 대한암학회지
Journal of the Korean Cancer Association
;
: 1093-1099, 2000.
Article
in Korean
| WPRIM
| ID: wpr-188549
ABSTRACT
PURPOSE:
Severe thrombocytopenia is a rare but life threatening side effect of anticancer chemotherapy. This study is for delineating risk factors for anticancer chemotherapy induced thrombocytopenia requiring platelet transfusion in cancer patients. MATERIALS ANDMETHODS:
Ninety seven cases of cancers (stomach cancer 37, lung cancer 31 and breast cancer 29) were included in this study design. Complete blood cell counts were done at day 1 and then twice a week to find lowerest thrombocyte count in each cycle. Discriminant analysis of risk factors for chemotherapy induced thrombocytopenia requiring platelet transfusion were performed.RESULTS:
Anticancer chemotherapy induced thrombocytopenia less than 150,000/ microliter developed in 18 cases (20.0%) at day 20.6 8.0 and mean platelet count was 111,060 35,360/ microliter. Thrombocytopenia less than 100,000/ microliter developed in 10 cases (10.3%) at day 20.2 6.9 and mean platelet count was 56,200 30,460/ microliter. Among them platelet transfusions were needed in 6 cases (6.2%). Using discrininant analysis, day 1 platelet count less than 150,000/ microliter with total lymphocyte count less than 900/ microliter were identified as risk factors for anticancer chemotherapy induced thrombocytopenia requiring platelet transfusion.CONCLUSION:
Thrombocytopenia less than 150,000 microliter with total lymphocyte count less than 900/ microliter before administrating anticancer drugs are high risk factors for platelet transfusion, and needed proper managements.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Platelet Count
/
Thrombocytopenia
/
Blood Cell Count
/
Blood Platelets
/
Breast Neoplasms
/
Risk Factors
/
Platelet Transfusion
/
Lymphocyte Count
/
Drug Therapy
/
Lung Neoplasms
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Cancer Association
Year:
2000
Type:
Article
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