The Usefulness of the Alanine Aminotransferase Test for Blood Donors / 대한수혈학회지
Korean Journal of Blood Transfusion
;
: 159-166, 2009.
Article
in Korean
| WPRIM
| ID: wpr-188576
ABSTRACT
BACKGROUND:
The usefulness of the alanine aminotransferase (ALT) test has been questioned after the introduction of anti-Hepatitis C virus (HCV) screening and the HCV nucleic acid test (NAT). A major proportion of the blood discarded according to a positive screening test is composed of ALT-high blood. This study was performed to investigate the usefulness of the ALT test.METHODS:
The number of donors with a high ALT level was analyzed using the 2007 database of 2,028,684 donors. The HBsAg and anti-HCV positive donors were grouped into the ALT or =90 IU/L group. Anti-HBc, anti-HBs and HBV DNA tests were performed for 402 high-ALT samples.RESULTS:
A total of 30,077 (1.5%) donors had an ALT> or =65 IU/L, and 18,594 (61.8%) of them had an ALT of 65~89 IU/L. The mean ages of the groups with ALT or =90 IU/L were 24, 26 and 25 years, respectively and HBsAg was positive in 0.13, 0.36 and 0.88%, respectively, and anti-HCV was positive in 0.30, 0.39 and 0.52%, respectively. HBV DNA was not detected in the 402 samples with an ALT> or =65 IU/L and a negative HBsAg test.CONCLUSION:
Based on an analysis of a donor databases, the HBV infection rates were higher in blood donors with high ALT. Although HBV DNA was not detected in the high-ALT samples with negative HBsAg, because of the high HBsAg positivity in the high-ALT samples, it would be desirable to retain the ALT screening test when considering the possibility of false negative reactions of the current hepatitis B screening test.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tissue Donors
/
Viruses
/
Blood Donors
/
DNA
/
Mass Screening
/
Alanine
/
Alanine Transaminase
/
False Negative Reactions
/
Hepatitis B
/
Hepatitis B Surface Antigens
Type of study:
Screening study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Blood Transfusion
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS