A Clinical Study on Sodium Valproate: Anticonvulsant and Side Effects

ABSTRACT

To assess the anticonvulsant effect and toxicity, 47 patients of seizure disorder were given Sodium Valproate by the administration method based on the principle of single dose plasma level (one point method). The evaluation periods of drug effects were from 3 months to over 12. Results are summarized as follows. 1. The age distribution of subjects ranges from 16 to 53 years old with mean age of 24.5. Ratio of male to female is 5.14.9. 2. Anticonvulsant effect of Na Valproate was good for simple and complex absences, fair for generalized tonicclonic seizures and partial seizures with secondary generalization, and poor for simple partial seizures. 3. Drowsiness was the most freguently notified side effect, and other symptoms, complained were epigastric discomfort, headache, dizziness, nausea, increased appetite and anorexia in that order of frequency. Laboratory tests including blood chemistry showed no significant changes.