Novel Germline Mutation of BRCA1 Gene in a 56-Year-Old Woman with Breast Cancer, Ovarian Cancer, and Diffuse Large B-Cell Lymphoma / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 534-538, 2015.
Article
in English
| WPRIM
| ID: wpr-189076
ABSTRACT
We report a case of a 56-year-old woman with breast cancer, ovarian cancer, and diffuse large B-cell lymphoma with a BRCA1 gene mutation. Evidence is mounting that there is a large increase in the risk for hematologic malignancies among patients with genetic changes in the BRCA pathways. The genomic analysis demonstrated a frameshift mutation in the BRCA1 gene 277_279delinsCC (Phe93fs). It is a novel BRCA1 mutation that has never been reported, and caused malignant lymphoma as well as breast and ovarian cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ovarian Neoplasms
/
Breast
/
Breast Neoplasms
/
Frameshift Mutation
/
Lymphoma, B-Cell
/
Germ-Line Mutation
/
Hematologic Neoplasms
/
Genes, BRCA1
/
Lymphoma
Limits:
Female
/
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2015
Type:
Article
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