Maturation of bone marrow-derived dendritic cells by a novel beta-glucan purified from Paenibacillus polymyxa JB115
Journal of Veterinary Science
;
: 187-189, 2011.
Article
in English
| WPRIM
| ID: wpr-189394
ABSTRACT
We investigated the immunostimulatory effects of a novel beta-glucan purified from Paenibacillus (P.) polymyxa JB115 on bone marrow-derived dendritic cells (DCs), a type of potent antigen-presenting cells. beta-glucan isolated from P. polymyxa JB115 enhanced the viability and induced the maturation of DCs. beta-glucan markedly increased the cytokine production of DCs and surface expression of DC markers. In addition, DCs treated with beta-glucan showed a higher capacity to stimulate allogeneic spleen cell proliferation compared to those treated with medium alone. These results demonstrate the effect of beta-glucan on DC maturation and may increase the use of beta-glucan.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Dendritic Cells
/
Bone Marrow Cells
/
Cell Survival
/
Immunophenotyping
/
Tumor Necrosis Factor-alpha
/
Interleukin-12
/
Beta-Glucans
/
Paenibacillus
/
Flow Cytometry
/
Mice, Inbred BALB C
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2011
Type:
Article
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