Roles of Matrix Metalloproteinases and Their Targets in Epileptogenesis and Seizures
Clinical Psychopharmacology and Neuroscience
;
: 45-52, 2013.
Article
in English
| WPRIM
| ID: wpr-189613
ABSTRACT
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) remodel the pericellular environment by regulating the cleavage of extracellular matrix proteins, cell surface components, neurotransmitter receptors, and growth factors, which together regulate cell adhesion, synaptogenesis, synaptic plasticity, and long-term potentiation. Increased MMP activity and dysregulation of the balance between MMPs and TIMPs have also been implicated in various pathological conditions. Recent studies have suggested that prolonged seizures are associated with high MMP levels in serum and neural tissues, and certain extracellular macromolecule targets may influence the pathogenesis of epilepsy and seizure. In this review, we discuss the roles of MMP activation in animal models of epilepsy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Seizures
/
Cell Adhesion
/
Extracellular Matrix Proteins
/
Receptors, Neurotransmitter
/
Long-Term Potentiation
/
Matrix Metalloproteinases
/
Models, Animal
/
Intercellular Signaling Peptides and Proteins
/
Metalloproteases
/
Epilepsy
Type of study:
Prognostic study
Language:
English
Journal:
Clinical Psychopharmacology and Neuroscience
Year:
2013
Type:
Article
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