Effect of Granulocyte Colony-Stimulating Factor on the Peripheral Nerves in Streptozotocin-Induced Diabetic Rat
Diabetes & Metabolism Journal
;
: 286-290, 2013.
Article
in English
| WPRIM
| ID: wpr-189617
ABSTRACT
There are controversial reports about the effect of granulocyte colony-stimulating factor (G-CSF) in peripheral nerve protection. Therefore, the present study aimed to investigate the effect of G-CSF on peripheral nerves in streptozotocin (STZ) induced diabetic rats. After STZ or vehicle injection, rats were divided into five groups (n=6) as follows normal+vehicle, normal+G-CSF (50 microg/kg for 5 days), diabetes mellitus (DM)+vehicle, DM+G-CSF (50 microg/kg for 5 days), and DM+G-CSF extension (50 microg/kg for 5 days and followed by two injections per week up to 24 weeks). Our results showed that the current perception threshold was not significantly different among experimental groups. G-CSF treatment inhibited the loss of cutaneous nerves and gastric mucosal small nerve fibers in morphometric comparison, but statistical significance was not observed. The present results demonstrated that G-CSF has no harmful but minimal beneficial effects with respect to peripheral nerve preservation in diabetic rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peripheral Nerves
/
Granulocyte Colony-Stimulating Factor
/
Streptozocin
/
Diabetes Mellitus
/
Granulocytes
/
Nerve Fibers
Limits:
Animals
Language:
English
Journal:
Diabetes & Metabolism Journal
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS