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Penicillamine-induced Elastosis Perforans Serpiginosa and Cutis Laxa in a Patient with Wilson's Disease
Annals of Dermatology ; : 468-471, 2010.
Article in English | WPRIM | ID: wpr-189834
ABSTRACT
Elastosis perforans serpiginosa (EPS) is a rare reactive perforating dermatosis that is characterized by the transepidermal elimination of abnormal elastic fibers. Penicillamine, which is one of the clear triggers for EPS, is a heavy metal chelator that is primarily used for disorders such as cystinuria and Wilson's disease. It may cause alterations in the dermal elastic tissue such as pseudo-pseudoxanthoma elasticum, acquired cutis laxa, EPS and anetoderma. Herein we present a case of cutis laxa and EPS in a 34-year-old man who was previously on a long-term, high-dose of penicillamine for Wilson's disease. The combination of EPS and cutis laxa induced by penicillamine has rarely been reported and we report the first such case in Korea.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Penicillamine / Skin Diseases / Cutis Laxa / Cystinuria / Elastic Tissue / Anetoderma / Hepatolenticular Degeneration / Korea Limits: Adult / Humans Country/Region as subject: Asia Language: English Journal: Annals of Dermatology Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Penicillamine / Skin Diseases / Cutis Laxa / Cystinuria / Elastic Tissue / Anetoderma / Hepatolenticular Degeneration / Korea Limits: Adult / Humans Country/Region as subject: Asia Language: English Journal: Annals of Dermatology Year: 2010 Type: Article