Chronic Antidepressant Administration Increases the Expression of PhosphoCREB(Phosphorylated Cyclic AMP Response Element Binding Protein) in Rat Hippocampus / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 992-998, 1998.
Article
in Korean
| WPRIM
| ID: wpr-189841
ABSTRACT
OBJECTIVES:
This study designed to assess the expression of phosphoCREB in rat hippocampus after chronic administration of various antidepressants in comparison with chronic administration of antipsychotic and antianxiety drugs.METHODS:
Male sprague-Dawley rats(200-300g) were used for this experiment. The subjects were divided into 6groups according to specific treatment agents(paroxetine, desipramine, moclobemide, haloperidol. lorazepam, vehicl) which were administered daily for 1day, 3days, 7days, and 14days by intraperitoneal injection repectively. Brains were removed 15 minutes after the last treatment. PhosphoCREB immunoreactivity was mesured by phosphoCREB(+) cell counts in hippocampus of rats.RESULTS:
Expression of phosphoCREB was significantly increased from day 3 in moclobemide group, from day 7 in paroxetine and desipramine groups, and increased most significantly from day 14 in all antidepressant-administered groups, with no increase in other tow groups(lorazepam and haloperidol group) throughout the experiment and even after 14 days of treatment.CONCLUSION:
These result suggest that increased expression of phosphoCREB after chronic administration of antidepressants, not of antipsychotic or antianxiety drugs, demonstrates pharmacological specificity of antidepressant treatment in rat hippocampus regardless of their receptor preference.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Brain
/
Cell Count
/
Sensitivity and Specificity
/
Rats, Sprague-Dawley
/
Paroxetine
/
Cyclic AMP
/
Response Elements
/
Moclobemide
/
Desipramine
/
Haloperidol
Type of study:
Diagnostic study
Limits:
Animals
/
Humans
/
Male
Language:
Korean
Journal:
Journal of Korean Neuropsychiatric Association
Year:
1998
Type:
Article
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