Functional Polymorphism in the Promoter Region of Matrix Metalloproteinase-9 is Strongly Associated with Acute Myocardial Infarction
Korean Circulation Journal
;
: 192-196, 2005.
Article
in English
| WPRIM
| ID: wpr-18989
ABSTRACT
BACKGROUND AND OBJECTIVES:
Matrix metalloproteinase-9 (MMP-9) plays an important role in the genesis of atherosclerotic plaque rupture and acute coronary syndrome (ACS), including an acute myocardial infarction (AMI). A single nucleotide polymorphism (SNP) in the MMP-9 promoter (-1562C>T) has recently been identified. This study investigated whether the SNP of the MMP-9 promoter is a significant risk factor for an AMI due to plaque rupture and if SNPs affect the transcription of the gene that elevates the MMP-9 expression level. SUBJECTS ANDMETHODS:
A polymerase chain reaction, followed by a restriction fragment length polymorphism analysis, was performed in 173 control participants and 206 AMI patients. The serum levels of MMP-9 in the groups with or without the SNP were measured, using ELISA, and compared.RESULTS:
There was a significantly higher incidence of the -1562C>T MMP-9 polymorphism in the AMI compared to the control group (27.6% vs. 17.9%, p=0.04). A multiple logistic regression analysis of the risk factors for coronary artery disease and the MMP-9 polymorphism showed the MMP-9 polymorphism to be an important factor in the prediction of an AMI (odds ratio 1.67, 95% confidence interval 1.02-2.67, p=0.04).CONCLUSION:
The -1562C>T polymorphism in the MMP-9 promoter is a definite risk factor for an AMI, and is associated with elevated MMP-9 expression. These results suggest that a SNP in the MMP-9 promoter is strongly associated with an Acute Myocardial Infarction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rupture
/
Coronary Artery Disease
/
Polymorphism, Restriction Fragment Length
/
Enzyme-Linked Immunosorbent Assay
/
Logistic Models
/
Polymerase Chain Reaction
/
Incidence
/
Risk Factors
/
Promoter Regions, Genetic
/
Matrix Metalloproteinase 9
Type of study:
Etiology study
/
Incidence study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Korean Circulation Journal
Year:
2005
Type:
Article
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