The Neuromuscular Blocking Effect of Mivacurium in Isolated Rat Phrenic-Hemidiaphragm with Long-term Phenytoin Pretreatment / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 237-242, 1997.
Article
in Korean
| WPRIM
| ID: wpr-190131
ABSTRACT
BACKGROUND:
Long-term phenytoin therapy induces resistance to the neuromuscular blocking effects of metocurine, atracurium, doxacurium, and pipecuronium. This study examine neuromuscu-lar blocking effect and recovery of mivacurium in isolated rat phrenic-hemidiaphragm with two-weeks phenytoin pretreatment.METHOD:
After the administration of 14 days of phenytoin 40 mg/kg, administered intraperitoneally twice daily (n=10), ED90, antagonism of neostigmine and 4-aminopyridine on the electrically evoked twitch response and train-of-four (TOF) stimulation were compared to control groups in isolated rat phrenic-hemidiaphragm preparation.RESULTS:
ED90 was significantly greater in the phenytoin group than in the control group (319 +/- 39.5 g vs. 209.5 +/- 52.2 g, respectively). After the administration of neostigmine 0.75 M, the recovery of the single twitch and TOF ratio were significantly lesser in the phenytoin group than in the control group (single twitch; 19.6 +/- 6.6% vs. 69.2 +/- 9.4%, TOF ratio; 0.258 +/- 0.149 vs. 0.543 +/- 0.1, respectively). After the administration of 4-aminopyridine 40uM, the recovery of the single twitch and TOF ratio were no significant differrence between the phenytoin group and the control group (twitch; 118.1 +/- 25.3% vs. 122.6 +/- 24.8%, TOF ratio; 0.937 +/- 0.051 vs. 0.949 +/- 0.067, respectively).CONCLUSION:
Long-term phenytoin therapy induces resistance to the neuromuscular blocking effects of mivacurium.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenytoin
/
Atracurium
/
4-Aminopyridine
/
Pipecuronium
/
Neuromuscular Blockade
/
Drug Interactions
/
Neostigmine
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
1997
Type:
Article
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