Effect of Probiotics on Symptoms in Korean Adults with Irritable Bowel Syndrome
Gut and Liver
;
: 101-107, 2009.
Article
in English
| WPRIM
| ID: wpr-190163
ABSTRACT
BACKGROUND/AIMS:
Irritable bowel syndrome (IBS) is a troublesome disease. Some strains of probiotics reportedly exert remarkable immunomodulatory effects, and so we designed a prospective double-blind randomized placebo-controlled clinical study to assess their effects in Korean adults with IBS.METHODS:
IBS patients who met Rome III criteria were randomly assigned to receive composite probiotics or placebo. A total of 20 billion lyophilized bacteria were administered twice daily for 8 weeks. Primary outcome variables were symptom scores consisting of abdominal pain, flatulence, defecation discomfort, and sum of symptom scores. A visual analogue scale was used to quantify the severity. Secondary outcome variables consisted of the quality of life and bowel habits including defecation frequency and stool form.RESULTS:
Thirty-six and 34 patients were randomized to the probiotics and placebo groups, respectively. Intention- to-treat analysis showed significant reductions in pain after 8 weeks of treatment -31.9 and -17.7 in the probiotics and placebo groups, respectively (p=0.045). The reductions in abdominal pain, defecation discomfort, and sum of scores were more significant in 58 patients with a score of at least 3 on the baseline stool-form scale.CONCLUSIONS:
Composite probiotics containing Bifidobacterium bifidum BGN4, Lactobacillus acidophilus AD031, and other species are safe and effective, especially in patients who excrete normal or loose stools.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quality of Life
/
Rome
/
Bacteria
/
Bifidobacterium
/
Abdominal Pain
/
Prospective Studies
/
Probiotics
/
Defecation
/
Irritable Bowel Syndrome
/
Flatulence
Type of study:
Controlled clinical trial
/
Diagnostic study
/
Observational study
Limits:
Adult
/
Humans
Country/Region as subject:
Europa
Language:
English
Journal:
Gut and Liver
Year:
2009
Type:
Article
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