Effect of Probiotics on Symptoms in Korean Adults with Irritable Bowel Syndrome
Gut and Liver
; : 101-107, 2009.
Article
in En
| WPRIM
| ID: wpr-190163
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS: Irritable bowel syndrome (IBS) is a troublesome disease. Some strains of probiotics reportedly exert remarkable immunomodulatory effects, and so we designed a prospective double-blind randomized placebo-controlled clinical study to assess their effects in Korean adults with IBS. METHODS: IBS patients who met Rome III criteria were randomly assigned to receive composite probiotics or placebo. A total of 20 billion lyophilized bacteria were administered twice daily for 8 weeks. Primary outcome variables were symptom scores consisting of abdominal pain, flatulence, defecation discomfort, and sum of symptom scores. A visual analogue scale was used to quantify the severity. Secondary outcome variables consisted of the quality of life and bowel habits including defecation frequency and stool form. RESULTS: Thirty-six and 34 patients were randomized to the probiotics and placebo groups, respectively. Intention- to-treat analysis showed significant reductions in pain after 8 weeks of treatment: -31.9 and -17.7 in the probiotics and placebo groups, respectively (p=0.045). The reductions in abdominal pain, defecation discomfort, and sum of scores were more significant in 58 patients with a score of at least 3 on the baseline stool-form scale. CONCLUSIONS: Composite probiotics containing Bifidobacterium bifidum BGN4, Lactobacillus acidophilus AD031, and other species are safe and effective, especially in patients who excrete normal or loose stools.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Quality of Life
/
Rome
/
Bacteria
/
Bifidobacterium
/
Abdominal Pain
/
Prospective Studies
/
Probiotics
/
Defecation
/
Irritable Bowel Syndrome
/
Flatulence
Type of study:
Clinical_trials
/
Diagnostic_studies
/
Observational_studies
Limits:
Adult
/
Humans
Country/Region as subject:
Europa
Language:
En
Journal:
Gut and Liver
Year:
2009
Type:
Article