Human Leukocyte Antigen-DRB1 Associations in Korean Juvenile Rheumatoid Arthritis
Journal of Rheumatic Diseases
;
: 182-186, 2014.
Article
in Korean
| WPRIM
| ID: wpr-190180
ABSTRACT
OBJECTIVE:
The aim of this study is to investigate the association of different subgroups of juvenile rheumatoid arthritis (JRA) with human leukocyte antigen (HLA) class II DR alleles.METHODS:
One hundred and nineteen Korean juvenile rheumatoid arthritis patients were classified as HLA-DRB1 allele. To assess the frequency, phenotype frequencies of all JRA cases and each subtypes were compared to those of 485 adult controls.RESULTS:
HLA-DRB1*01 was associated with increased risk of JRA. Furthermore, DRB1*01 was associated with polyarticular JRA and pauciarticular JRA. The frequencies of DRB1*14 and DRB1*15 were higher in systemic JRA patients than the controls.CONCLUSION:
The data of this study on Korean children with JRA suggests that HLA-DRB1*01 was associated with the susceptibility of JRA. The study should be extended to include larger numbers of patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Arthritis, Juvenile
/
Alleles
/
HLA-DRB1 Chains
/
Leukocytes
Limits:
Adult
/
Child
/
Humans
Language:
Korean
Journal:
Journal of Rheumatic Diseases
Year:
2014
Type:
Article
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