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Urinary Hypoxia-Inducible Factor-1alpha Levels Are Associated with Histologic Chronicity Changes and Renal Function in Patients with Lupus Nephritis
Yonsei Medical Journal ; : 587-592, 2012.
Article in English | WPRIM | ID: wpr-190361
ABSTRACT

PURPOSE:

Tubulointerstitial hypoxia in the kidney is considered a hallmark of injury and a mediator of the progression of tubulointerstitial fibrosis. Hypoxia-inducible factor-1alpha (HIF-1alpha), a master transcription factor in cellular adaptation to hypoxia, regulates a wide variety of genes, some of which are closely associated with tissue fibrosis. The present study set out to characterize urinary HIF-1alpha expressions in patients with lupus nephritis (LN) and to explore whether urinary HIF-1alpha expressions are associated with histologic chronicity changes and renal function. MATERIALS AND

METHODS:

Urinary HIF-1alpha levels were measured by enzyme-linked immunosorbent assays in 42 patients with LN and in 30 healthy controls. Activity and chronicity indexes as well as tubular HIF-1alpha expressions were analyzed for each specimen.

RESULTS:

Urinary HIF-1alpha levels were higher in LN patients than in healthy controls (3.977+/-1.696 vs. 2.153+/-0.554 ng/mL, p0.05).

CONCLUSION:

Urinary HIF-1alpha levels were elevated in LN patients and were associated with histologic chronicity changes and renal function, indicating that HIF-1alpha might contribute to histologic chronicity in LN.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Lupus Nephritis / Enzyme-Linked Immunosorbent Assay / Hypoxia-Inducible Factor 1, alpha Subunit / Kidney Limits: Adolescent / Adult / Female / Humans / Male Language: English Journal: Yonsei Medical Journal Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Lupus Nephritis / Enzyme-Linked Immunosorbent Assay / Hypoxia-Inducible Factor 1, alpha Subunit / Kidney Limits: Adolescent / Adult / Female / Humans / Male Language: English Journal: Yonsei Medical Journal Year: 2012 Type: Article