Natural Killer Cell Activity in Rheumatoid Arthritis Measured by a Single Cell Cytotoxicity Assay
Yonsei Medical Journal
;
: 160-165, 1988.
Article
in English
| WPRIM
| ID: wpr-190443
ABSTRACT
The natural killer(NK) cell activity of mononuclear cells (MNC) from peripheral blood (PB) and synovial fluid (SF) of 40 rheumatoid arthritis(RA) patients was investigated by employing 51-chromium-(51Cr) release microcytotoxicity and single cell cytotoxicity assays against K562 target cells. It has been revealed that SF-MNC from RA patients showed a significantly lower NK activity than PB-MNC from the same patients and this might be due to an impaired target binding capacity of the effector cells and not due to a deficiency of active NK cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arthritis, Rheumatoid
/
Synovial Fluid
/
In Vitro Techniques
/
Cytotoxicity Tests, Immunologic
/
Comparative Study
/
Killer Cells, Natural
/
Chromium Radioisotopes
/
Cytotoxicity, Immunologic
/
Middle Aged
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Yonsei Medical Journal
Year:
1988
Type:
Article
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