A Case of Pellagra Induced by Isoniazid during Treatment of Pulmonary Tuberculosis / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 180-182, 2004.
Article
in Korean
| WPRIM
| ID: wpr-191072
ABSTRACT
A Case of Pellagra Induced by Isoniazid during Treatment of Pulmonary Tuberculosis Pellagra is a disease caused by a deficiency of nicotinic acid or niacin. It is mostly found among people eating corn-based diets in parts of China, Africa and India. It is also induced by drugs, such as isoniazid or 5-fluorouracil. Isoniazid inhibits the conversion of tryptophan to niacin and may induce pellagra, particularly in poorly nourished patients. Pellagra should be suspected whenever tuberculous patients under the treatment with isoniazid develop mental, neurological or gastrointestinal symptoms, even in the absence of typical skin changes. Herein, our experienced of a case of pellagra induced by isoniazid during treatment of pulmonary tuberculosis is reported. The patient was referred due to a skin rash and drowsy mental status. Her skin lesion developed during treatment for pulmonary tuberculosis. Her symptoms were improved after discontinuation of antituberculous agents and on the administration of nicotinamide.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pellagra
/
Skin
/
Tryptophan
/
Tuberculosis, Pulmonary
/
China
/
Niacinamide
/
Africa
/
Diet
/
Eating
/
Exanthema
Limits:
Humans
Country/Region as subject:
Africa
/
Asia
Language:
Korean
Journal:
Tuberculosis and Respiratory Diseases
Year:
2004
Type:
Article
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