A case of hypokalemic perodic paralysis induced by hyperinsulinemia / 대한내과학회지
Korean Journal of Medicine
;
: 692-696, 2005.
Article
in Korean
| WPRIM
| ID: wpr-191103
ABSTRACT
Hypokalemia periodic paralysis, a clinical syndrome characterised by systemic weakness and low serum potassium, is a rare but treatable cause of acute weakness. Attacks of flaccid paralysis can be associated with hypokalemia triggered by insulin. Insulin reduce the conductance of the inward rectifier K+ channel for outward-flowing currents. Therefore, insulin potentiates depolarization of hypokalmeic periodic paralysis. We have experienced a case of hypokalemic periodic paralysis induced by hyperinsulinemia in 38-year old man, with complaint of intermittent paralysis of extremities. On admission, serum K+ was 2.1 mEq/L. He was no family history of muscle weakness. Thyroid function was normal. Serum levels of aldosterone, renin and cortisol were normal. Random plasma glucose level was 129 mg/dL and serum insulin was 131 uIU/mL. Shortly after intravenous supplementation of potassium, muscle weakness was improved. Oral glucose tolerance test revealed impaired glucose tolerance and hyperresponse of insulin and phosphate.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paralysis
/
Potassium
/
Thyroid Gland
/
Blood Glucose
/
Hydrocortisone
/
Renin
/
Muscle Weakness
/
Hypokalemic Periodic Paralysis
/
Potassium Channels, Inwardly Rectifying
/
Aldosterone
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2005
Type:
Article
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