Comparison of Methods for the Detection of Anti-HBs for Hepatitis B Vaccination Program in Korea / 예방의학회지
Korean Journal of Preventive Medicine
;
: 226-230, 2000.
Article
in Korean
| WPRIM
| ID: wpr-191286
ABSTRACT
OBJECTIVES:
The purpose of this study was to suggest a proper method for the detection of heaptitis B surface antibody(anti-HBs) in a screening program for hepatitis B vaccination.METHODS:
Sensivitity, specificity and predictive values were compared between Immunochromatographic assay (ICA) and passive hemagglutination(PHA) in 978 subjects(565 males, 413 females, 19-78 years ranging in age, mean 46.5 years old). EIA was used as a standard method for the detection of HBsAb.RESULTS:
Sensitivity in the detection of anti-HBs of PHA and ICA was 88.7% and 94.9%, specificity was 94.3% and 96.6%, negative predictive value was 96.5% and 98.0%, and positive predictive value was 82.3% and 91.3%, respectively. False negative rate(11.3%) of PHA was higher than that(5.1%) of ICA. The higher the titer of anti-HBs in EIA was, the lower the false negative rate was. There was no false negative result in the cases with 101mIU/ml or more in EIA.CONCLUSION:
We suggest that ICA should be the choice of screening method in the detection of anti-HBs in Hepatitis B vaccination program.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Mass Screening
/
Chromatography, Affinity
/
Sensitivity and Specificity
/
Vaccination
/
Hepatitis
/
Hepatitis B
/
Korea
Type of study:
Diagnostic study
/
Screening study
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Preventive Medicine
Year:
2000
Type:
Article
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