Serum Cystatin C Reflects the Progress of Albuminuria
Diabetes & Metabolism Journal
;
: 602-609, 2011.
Article
in English
| WPRIM
| ID: wpr-191388
ABSTRACT
BACKGROUND:
Research on the relationship between urinary albumin excretion and serum cystatin C in diabetes is restricted to cross-sectional studies. In this study, we investigated how well serial measurements of serum cystatin C level reflect changes in the urinary albumin excretion rate.METHODS:
We enrolled and retrospectively collected data on 1,058 participants with type 2 diabetes who were older than 18 years and who had more than 3 years of follow-up with serial measurements of albuminuria and serum cystatin C at an outpatient clinic.RESULTS:
With the use of a linear mixed model, we found that the albuminuria level for each patient over time corresponded with the annual change in serum cystatin C-based estimated glomerular filtration rate (cysC-eGFR) but did not correspond with the creatinine-based eGFR calculated by the modification of diet in renal disease formula (MDRD-eGFR). The discrepancy in the direction of the trend was smaller with cysC-eGFR than with MDRD-eGFR.CONCLUSION:
Serum cystatin C level reflects the trend in albuminuria level more accurately than serum creatinine level in Korean type 2 diabetes mellitus patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Outpatients
/
Retrospective Studies
/
Follow-Up Studies
/
Creatinine
/
Diabetes Mellitus, Type 2
/
Diabetic Nephropathies
/
Diet
/
Albuminuria
/
Cystatin C
/
Glomerular Filtration Rate
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Diabetes & Metabolism Journal
Year:
2011
Type:
Article
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