Effect of Transdermal Fentanyl Patches on the Motility of the Sphincter of Oddi
Gut and Liver
;
: 368-372, 2010.
Article
in English
| WPRIM
| ID: wpr-191438
ABSTRACT
BACKGROUND/AIMS:
Pain is one of the most troublesome symptoms of pancreatitis. Transdermal fentanyl patches (TFPs) are long-acting analgesics with a reduced risk of dependency. This prospective study evaluated the effect of TFPs on sphincter of Oddi (SO) motility for the management of pain in pancreatitis.METHODS:
SO manometry (SOM) was performed using triple-lumen catheters anterogradely inserted through the percutaneous transhepatic route during cholangioscopy in 16 patients. The basal pressure, amplitude, and frequency of the SO were assessed before and after applying a TFP at 24 hour at doses of 25 and 12.5microgram/hr, respectively.RESULTS:
Two of 16 patients receiving a 25microgram/hr. TFP were excluded because of adverse side effects (headache and/or nausea). The mean basal pressure, amplitude, and frequency of SOM did not change significantly in the 25microgram/hr TFP group (n=4 patients). Parameters of SO function also did not significantly change in the 12.5microgram/hr TFP group (n=11 patients).CONCLUSIONS:
TFPs below a dose of 25microgram/hr may not affect the motility of the SO. Administration of TFPs at lower dosages seems to be a safe analgesic treatment for the pain control of patients with pancreatitis without affecting the function of the SO.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreatitis
/
Fentanyl
/
Prospective Studies
/
Dependency, Psychological
/
Catheters
/
Analgesics
/
Manometry
/
Sphincter of Oddi
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Gut and Liver
Year:
2010
Type:
Article
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