Evaluation of the Interaction between Intrathecal 5-Hydroxytryptamine and Adenosine in the Formalin Test in a Rat Model / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 870-876, 2004.
Article
in Korean
| WPRIM
| ID: wpr-191473
ABSTRACT
BACKGROUND:
Spinal 5-hydroxytryptamine (5-HT) and adenosine have been shown to display an antinociceptive effect. The authors evaluated the characteristics of this drug interaction after the concurrent delivery of 5-HT and adenosine in combination at the spinal level.METHODS:
Catheters were inserted into the intrathecal space of male Sprague-Dawley rats. Nociception was induced by subcutaneous injection of formalin solution (5%, 50microliter) into the hindpaw. Fixed dose analysis and isobolographic analysis were used to determine the properties of the interaction.RESULTS:
Intrathecal 5-HT dose-dependently suppressed the flinching response during phase 1 of the formalin test, whereas adenosine failed to affect the phase 1 flinching response. Both drugs attenuated the phase 2 flinching response in a dose-dependent manner. The intrathecal combination of 5-HT with a fixed dose of adenosine in phase 1 increased the antinociception of 5-HT alone, and isobolographic analysis in phase 2 revealed a synergistic interaction between intrathecal 5-HT and adenosine.CONCLUSIONS:
Intrathecal 5-HT reduced the facilitated pain state and acute pain. In contrast, intrathecal adenosine alone did not affect acute pain significantly, but attenuated the facilitated pain state. Furthermore, 5-HT interacted synergistically with adenosine at the spinal level. Thus, this combination may offer a potential remedy for the treatment of tissue injury pain.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spinal Cord
/
Pain Measurement
/
Serotonin
/
Adenosine
/
Rats, Sprague-Dawley
/
Models, Animal
/
Drug Interactions
/
Catheters
/
Acute Pain
/
Nociception
Limits:
Animals
/
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2004
Type:
Article
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