Association Between Suicide Attempts in Patients With Depressive Disorder and Tryptophan Hydroxylase A218C Polymorphism / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 142-152, 2008.
Article
in Korean
| WPRIM
| ID: wpr-191646
ABSTRACT
OBJECTIVES:
Several lines of evidence suggest the serotonergic dysfunction involved in the biological susceptibility of suicide. Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of serotonin, plays a vital role in serotonin metabolism. In a case-control study, we investigated whether the TPH gene was a susceptible factor for suicidal behavior in depressive patients.METHODS:
The subjects were 218 depressed patients who attempted suicide and visited emergency rooms in multi-medical centers. One hundred thirty hospitalized non-suicidal depressed patients and the 161 normal controls were matched with the suicidal group. Individuals in all 3 groups were evaluated independently by a Structured Clinical Interview for the purpose of establishing a DSM-IV criteria diagnosis (SCID). The severity of depressive symptoms was evaluated using Hamilton depression rating scale (HDRS).RESULTS:
There was no significant difference in genotype distributions and allele frequencies of TPH intron 7 A218C polymorphisms among 3 groups. Furthermore, no significant difference in genotype counts and allele frequencies of the polymorphisms was found among lethal suicidal depressed patients, non-suicidal depressed patients and the normal controls.CONCLUSION:
This study suggests that the A218C polymorphism of the TPH gene is unlikely to have a major effect on the susceptibility of suicidal behaviors in depressive patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Suicide
/
Suicide, Attempted
/
Tryptophan
/
Tryptophan Hydroxylase
/
Introns
/
Serotonin
/
Case-Control Studies
/
Diagnostic and Statistical Manual of Mental Disorders
/
Depression
/
Depressive Disorder
Type of study:
Observational study
/
Qualitative research
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Journal of Korean Neuropsychiatric Association
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS