G-protein beta3 Subunit Gene 825C/T Polymorphism Is Not Associated with Olanzapine-Induced Weight Gain in Korean Schizophrenic Patients
Psychiatry Investigation
;
: 39-43, 2009.
Article
in English
| WPRIM
| ID: wpr-191790
ABSTRACT
OBJECTIVE:
Weight gain is a possible adverse effect of the use of antipsychotics, and is an important factor for long-term health and treatment compliance. Olanzapine is an atypical antipsychotic known to cause considerable weight gain. A relationship between weight gain and the G protein beta3 subunit gene (GNB3) 825C/T polymorphism has been reported. We therefore examined this possible association in a Korean schizophrenic patient group receiving olanzapine treatment.METHODS:
Weight and height measurements were obtained prior to starting olanzapine and measured again after long-term treatment. Genotyping for the 825C/T polymorphism was performed using a PCR-based method.RESULTS:
We found that long-term treatment with olanzapine resulted in mean gains in weight and body mass index (BMI) of 5.2 kg and 1.93 kg/m2, respectively. There was a no significant difference in the mean body weight change from baseline to the endpoint after olanzapine treatment between the genotype groups (p=0.796). There were also no significant differences in genotype or allele frequencies between the severe weight-gain (more than 10%) and minimal weight-gain (less than 10%) groups (chi-square=0.037, p=0.98; chi-square=0.020, p=0.89).CONCLUSION:
The finding from this study thus does not support a relationship between the GNB3 825C/T polymorphism and weight gain in Korean schizophrenic patients receiving olanzapine treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Schizophrenia
/
Antipsychotic Agents
/
Benzodiazepines
/
Body Weight Changes
/
Weight Gain
/
Body Mass Index
/
Compliance
/
GTP-Binding Proteins
/
Heterotrimeric GTP-Binding Proteins
/
Gene Frequency
Limits:
Humans
Language:
English
Journal:
Psychiatry Investigation
Year:
2009
Type:
Article
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