Moderate Exercise Enhances the Production of Interferon-γ and Interleukin-12 in Peripheral Blood Mononuclear Cells
Immune Network
;
: 186-191, 2017.
Article
in English
| WPRIM
| ID: wpr-191875
ABSTRACT
The purpose of this study was to explore the effect of two months moderate exercise on levels of IFN-γ, IL-12, IL-6 and IL-4 in serum and supernatants of in vitro mitogen-activated (PHA for 48 h) whole blood (WB) and peripheral blood mononuclear cells (PBMCs). Sixteen healthy males participated in running program (30 min/day, 5 days/week). Blood samples were collected in three stages; 24 h before to start exercise, 48 h and two months after the last session of the exercise. The samples were analyzed for the cytokines by ELISA. The levels of IFN-γ and IL-12 were increased significantly in activated PBMCs culture after exercise and were back to normal level after two months rest. A significant elevation of IFN-γ/IL-4 ratio was observed in activated PBMCs culture by acting possibly on IFN-γ. The results suggest that short moderate intensity exercise enhances Th1 immune inflammatory and anti-allergic conditions in response to mitogen.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Running
/
In Vitro Techniques
/
Enzyme-Linked Immunosorbent Assay
/
Cytokines
/
Interleukin-4
/
Interleukin-6
/
Interleukin-12
/
Inflammation
Limits:
Humans
/
Male
Language:
English
Journal:
Immune Network
Year:
2017
Type:
Article
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