The bone regenerative effect of silk fibroin mixed with platelet-rich fibrin (PRF) in the calvaria defect of rabbit
Journal of the Korean Association of Oral and Maxillofacial Surgeons
;
: 250-254, 2010.
Article
in Korean
| WPRIM
| ID: wpr-191910
ABSTRACT
INTRODUCTION:
This study evaluated the bone regenerative effect of silk fibroin mixed with platelet-rich fibrin (PRF) of a bone defect in rabbits. MATERIALS ANDMETHODS:
Ten New Zealand white rabbits were used for this study and bilateral round shaped defects were formed in the parietal bone (diameter 8.0 mm). The silk fibroin mixed with PRF was grafted into the right parietal bone (experimental group). The left side (control group) was grafted only PRF. The animals were sacrificed at 4 weeks and 8 weeks. A micro-computerized tomography (microCT) of each specimen was taken. Subsequently, the specimens were decalcified and stained for histological analysis.RESULTS:
The average value of plane film analysis was higher in the experimental group than in the control group at 4 weeks and 8weeks after surgery. However, the difference was not statistically significant.(P>0.05) The tissue mineral density (TMD) in the experimental group at 4 weeks after surgery was significantly higher than the control group.(P<0.05)CONCLUSION:
Silk fibroin can be used as a scaffold of PRF for rabbit calvarial defect repair.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parietal Bone
/
Skull
/
Bone Regeneration
/
Fibrin
/
Transplants
/
Silk
/
Fibroins
Limits:
Animals
Language:
Korean
Journal:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Year:
2010
Type:
Article
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