Can Peritoneal Dialysis Remove Endothelin-1 after Cardiopulmonary Bypass for Repair of Congenital Heart Disease? / 대한흉부외과학회지
The Korean Journal of Thoracic and Cardiovascular Surgery
;
: 247-255, 2007.
Article
in Korean
| WPRIM
| ID: wpr-191972
ABSTRACT
BACKGROUND:
Lung injury that follows bypass has been well described. It is manifested as reduced oxygenation and lung compliance and, most importantly, increased pulmonary vascular resistance reactivity; this is a known cause of morbidity and mortality after repair of congenital heart disease. Injury to the pulmonary vascular endothelium, and its associated alterations of endothelin-1, is considered to be a major factor of bypass-induced lung injury. Removing endothelin-1 after bypass may attenuate this response. This study measured the concentration of serum and peritoneal effluent endothelin-1 after performing bypass to determine if endothelin-1 can be removed via peritoneal dialysis. MATERIAL ANDMETHOD:
From March 2005 to March 2006, 18 patients were enrolled in this study. Peritoneal catheters were placed at the end of surgery. Serum samples were obtained before and after bypass, and peritoneal effluents were obtained after bypass. Endothelin-1 was measured by enzyme linked immunosorbent assay (ELISA).RESULT:
In the patients with a severe increase of the pulmonary artery pressure or flow, the mean preoperative plasma endothelin-1 concentration was significantly higher than that in the patients who were without an increase of their pulmonary artery pressure or flow (4.2 vs 1.8 pg/mL, respectively, p<0.001). The mean concentration of plasma endothelin-1 increased from a preoperative value of 3.61+/-2.17 to 5.33+/-3.72 pg/ml immediately after bypass. After peritoneal dialysis, the mean plasma endothelin-1 concentration started to decrease. Its concentration at 18 hours after bypass was significantly lower than the value obtained immediately after bypass (p=0.036).CONCLUSION:
Our data showed that the plasma endothelin-1 concentration became persistently decreased after starting peritoneal dialysis, and this suggests that peritoneal dialysis can remove the circulating plasma endothelin-1.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxygen
/
Plasma
/
Pulmonary Artery
/
Vascular Resistance
/
Enzyme-Linked Immunosorbent Assay
/
Endothelium, Vascular
/
Cardiopulmonary Bypass
/
Lung Compliance
/
Mortality
/
Peritoneal Dialysis
Type of study:
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
The Korean Journal of Thoracic and Cardiovascular Surgery
Year:
2007
Type:
Article
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