Efficacy and Safety of Uro-Vaxom Treatment for Patients with Recurrent Cystitis: An Open Multicenter Study / 대한비뇨기과학회지
Korean Journal of Urology
;
: 428-432, 2007.
Article
in Korean
| WPRIM
| ID: wpr-191980
ABSTRACT
PURPOSE:
We wanted to investigate the efficacy and safety of the immunotherapeutic Uro-Vaxom for treating uncomplicated recurrent cystitis in female patients only. MATERIALS ANDMETHODS:
Adult female patients were enrolled in this multicenter, open-label study if they had acute cystitis at the enrollment visit and positive results on urine culture (> or =10(3)CFU/ml). The patients were treated for 3 months with one capsule daily of Uro-Vaxom after antibiotic therapy, and they were observed for another 3 months. The primary efficacy criteria were the cystitis recurrence rates over 6 months, the distribution of cystitis and the proportion of patients with cystitis.RESULTS:
A total of 50 patients were evaluated. During the 6-month trial, the number of cystitis recurrences was significantly reduced in comparison with the 6-month pretrial period (on the average 0.64 as compared to 3.0 recurrences, respectively p<0.001). The incidences of frequency, urgency and dysuria remained low until the end of the trial. Uro-Vaxom was well tolerated side-effects were mentioned by 8% of the 50 patients, and there was no case leading to treatment withdrawal.CONCLUSIONS:
Uro-Vaxom significantly reduced the incidence of cystitis during the 6 months of this study, including the 3 months of treatment. These results demonstrate that Uro-Vaxom is a valuable agent for prophylaxis of recurrent cystitis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Incidence
/
Cystitis
/
Escherichia coli
/
Dysuria
Type of study:
Controlled clinical trial
/
Incidence study
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Urology
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS