Modulation of Melanin Synthesis by Amaranthus spp. L Seed Extract in Melan-a Cells
Natural Product Sciences
; : 168-174, 2016.
Article
in En
| WPRIM
| ID: wpr-192322
Responsible library:
WPRO
ABSTRACT
Anti-melanogenic effects of amaranth (AT), one of the key source of squalene, were investigated in melanocytes. Amaranth seed powder was extracted with water and melan-a cells were treated with various concentrations of AT. By using HPLC, content of myo-inositol, one of potential active components, was measured in the crude extract of AT.AT reduced the melanin content in melan-a melanocytes and down-regulated melanogenic enzyme activity such as tyrosinase, TRP-1 and TRP-2. By regulating melanogenic enzyme activity, AT may be a potential natural source for whitening agent. Myo-inositol was detected in AT by HPLC and may be one of the active compounds from AT involved in the regulation of anti-melanogenesis. In this study, we demonstrated that AT has anti-melanogenesis properties. This new function of amaranth may be useful in the development of new skin-whitening products and its value as food.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Squalene
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Water
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Chromatography, High Pressure Liquid
/
Monophenol Monooxygenase
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Amaranthus
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MART-1 Antigen
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Melanins
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Melanocytes
Language:
En
Journal:
Natural Product Sciences
Year:
2016
Type:
Article