The Clinical Characteristics and Predictive Factors of Stage IV Breast Cancer at the Initial Presentation: A Review of a Single Institute's Data / 한국유방암학회지
Journal of Breast Cancer
;
: 101-106, 2007.
Article
in English
| WPRIM
| ID: wpr-192421
ABSTRACT
PURPOSE:
The aim of this study is to evaluate stage IV breast cancer at the initial presentation by the review of a single institute' data. We also tried to figure out the factors to predict stage IV breast cancer.METHODS:
We reviewed the prospectively collected database of 1,424 consecutive patients with primary breast cancer at the National Cancer Center in Korea from October 2000 to January 2005.RESULTS:
The proportion of stage IV breast cancer was 2.7% (38/1,424). The median tumor size of the stage IV patients was 4.1 cm. The most common metastatic site was bone (47.4%) followed by lung (44.7%) and liver (36.8%). Metastases were found in 0.9% (6/672) of the T1 tumors, 2.4% (13/535) of the T2 tumors, 8.3% (4/48) of the T3 tumors, and 27.1% (13/48) of the T4 tumors (p or =2 cm) (p=0.026), positive lymph node status (p104 IU/L) (p=0.013), aspartate transferase (>40 IU/L) (p=0.003) and CA15-3 (>32 U/mL) (p=0.025).CONCLUSION:
Our study showed that the factors to predict distant metastasis of breast cancer were large size of tumor, positive lymph node status, elevated alkaline phosphatase, aspartate transferase and CA15-3. Therefore breast cancer patients with those clinical characteristics should be carefully evaluated to detect distant metastasis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transferases
/
Breast
/
Breast Neoplasms
/
Multivariate Analysis
/
Prospective Studies
/
Aspartic Acid
/
Alkaline Phosphatase
/
Korea
/
Liver
/
Lung
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Breast Cancer
Year:
2007
Type:
Article
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