The Effects of Intravenous Patient-Controlled Analgesia using Morphine or Nalbuphine to Postoperative Respiratory Depression / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 391-398, 1996.
Article
in Korean
| WPRIM
| ID: wpr-192739
ABSTRACT
BACKGROUND:
The aim of this study was to evaluate the effects of respiratory depression of IV-PCA using morphine which has potent respiratory depression or nalbuphine which has less potent respiratory depression among opioids.METHODS:
Forty patients were divided into two groups; Group M was used morphine, and Group N was used nalbuphine as a drug for IV-PCA. When patient emerges from general anesthesia, Group M was given initial bolus of 0.1 ml/kg of 0.1% morphine solution and connected Basal Bolus PCA infusor R containing morphine 50 mg per 40 ml in normal saline. Group N, similarly Group M, was given initial bolus of 0.1 ml/kg of 0.1% nalbuphine solution, and connected PCA infusor containing nalbuphine 50 mg per 40 ml in normal saline. To compare respiratory depression, arterial blood gas analyses were done preoperatively and at 1, 6 and 12 hour after IV-PCA. Simultaneously, analgesic and side effects were evaluated.RESULTS:
There were no remarkable respiratory depression such as hypercarbia(PaCO2 > 50 mmHg), hypoxemia(PaO2 < 60 mmHg) and slow respiratory rate in both groups. Analgesic and side effects were similar in both groups.CONCLUSIONS:
We conclude that IV-PCA using morphine or nalbuphine is relatively effective and safe method for the postoperative pain control. Ordinarily, IV-PCA dose not induce respiratory depression unless overdose in careless or mistaken mishaps are developed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pain, Postoperative
/
Respiratory Insufficiency
/
Blood Gas Analysis
/
Infusion Pumps
/
Passive Cutaneous Anaphylaxis
/
Analgesia, Patient-Controlled
/
Respiratory Rate
/
Analgesics, Opioid
/
Anesthesia, General
/
Morphine
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
1996
Type:
Article
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