Dapsone-induced drug reaction with eosinophilia and systemic symptoms syndrome, misdiagnosed as lymphoma
Allergy, Asthma & Respiratory Disease
;
: 400-404, 2013.
Article
in Korean
| WPRIM
| ID: wpr-192741
ABSTRACT
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening adverse drug reaction with systemic manifestations. Dapsone is known to be useful for treatment of leprosy and various dermatologic conditions. We report a patient with prurigo pigmentosa who developed DRESS syndrome after dapsone treatment. She presented with lymphadenopathy, fever, eosinophilia, skin rash, and elevated liver enzymes. Initial lymph node and skin biopsy was suggestive of peripheral T-cell lymphoma. Initially, she was treated with chemotherapy. A week later after complete remission of skin symptoms, new skin lesions recurred. TCR-gene rearrangement was examined to show negative results and she was diagnosed as dapsone induced DRESS syndrome. This case emphasizes the importance of differential diagnosis of lymphoma and DRESS syndrome.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prurigo
/
Skin
/
Biopsy
/
Lymphoma, T-Cell, Peripheral
/
Pseudolymphoma
/
Dapsone
/
Diagnosis, Differential
/
Drug Hypersensitivity
/
Drug Therapy
/
Drug-Related Side Effects and Adverse Reactions
Type of study:
Diagnostic study
Limits:
Humans
Language:
Korean
Journal:
Allergy, Asthma & Respiratory Disease
Year:
2013
Type:
Article
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