Effects of Propofol on Arginine Vasopressin-induced Contraction in Isolated Human Gastroepiploic Artery / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 662-668, 2008.
Article
in Korean
| WPRIM
| ID: wpr-192861
ABSTRACT
BACKGROUND:
Arginine vasopressin has been used by prophylactic treatment of vasodilatory shock during coronary artery bypass graft (CABG). Vasopressin may be a cause of spasm in graft artery during CABG. We evaluated the effect of propofol on vasopressin-induced contraction in human gastroepiploic artery (GEA).METHODS:
Human GEA were obtained from 35 patients (43-74 yr), undergoing subtotal gastrectomy. Vasopressin-induced a concentration contractions (10(-9) to 10(-6) M) were measured after exposed to without propofol, propofol 10(-5), 10(-4), 10(-3) M. After endothelium denuding vasopressin-induced a concentration contractions were measured with or without propofol 10(-3) M in calcium free solution. In the denuded vascular rings, with or without pretreatment of glibenclamide (10(-5) M), nicorandil (10(-5) M), or diltiazem (10(-5) M) were exposed to with or without propofol 10(-3) M, and vasopressin-induced concentration contractions were measured.RESULTS:
Vasopressin-induced concentration contraction on human GEA was independent of functional endothelium. Propofol (10(-4), 10(-3) M) attenuated the vasopressin-induced contraction in the human GEA. Diltiazem attenuated the vasopressin-induced contraction in the human GEA. ATP-sensitive potassium channel does not affect the inhibition effect of propofol on vasopressin-induced contractionCONCLUSIONS:
Usual anesthetic dose of propofol does not inhibit vasopressin-induced contraction on human GEA. High dose (>10(-4) M) propofol attenuated vasopresssi-induced contraction on GEA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arginine
/
Arteries
/
Shock
/
Spasm
/
Arginine Vasopressin
/
Vasopressins
/
Diltiazem
/
Potassium Channels
/
Propofol
/
Coronary Artery Bypass
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2008
Type:
Article
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