The Role of Central Group I mGluRs for CFA-induced Knee Joint Pain Model in Rats / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 504-512, 2007.
Article
in Korean
| WPRIM
| ID: wpr-193260
ABSTRACT
BACKGROUND:
Glutamate is the predominant excitatory neurotransmitter in the central and peripheral nervous system and has known to be involved in nociceptive transmission and central sensitization. It acts through ligand gated ionotropic glutamate receptors (iGluRs) and G protein-coupled metabotropic glutamate receptors (mGluRs). And mGlu 1, 5 receptors have been recognized to play a role in nociceptive processing. We want to investigate whether central mGluR1 and mGluR5 antagonists could reverse the behavioral signs of weight bearing and secondary mechanical hyperalgesia induced by chronic knee joint inflammation.METHODS:
MGluR1 antagonist, (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA 25, 50, 100 microM/10 microliter, n = 7 per group) and selective mGluR5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine (MPEP 25, 100, 200 nM/10 microliter, n = 7 per group) were injected intrathecally 5 days after Complete Freund's Adjuvant (CFA, 150 microliter) injection into knee joint and behavior signs of weight bearing and secondary mechanical hyperalgesia were observed.RESULTS:
CFA significantly reduced the magnitude of right hind paw weight bearing and decreased the withdrawal threshold to mechanical stimulation compared to contralateral side. Higher dose of AIDA (100 microM) significantly reversed the reduction of weight bearing, but MPEP did not. AIDA reversed the decrease of the paw withdrawal threshold to mechanical stimulation at the dosage of 50 and 100 microM respectively. MPEP significantly increased the paw withdrawal threshold to mechanical stimulation in a dose dependent manner.CONCLUSIONS:
Group I mGluRs were involved in maintenance of primary and secondary mechanical hyperalgesia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arthritis
/
Freund's Adjuvant
/
Weight-Bearing
/
Receptors, Metabotropic Glutamate
/
Peripheral Nervous System
/
Neurotransmitter Agents
/
Glutamic Acid
/
Receptors, Ionotropic Glutamate
/
Central Nervous System Sensitization
/
Hyperalgesia
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2007
Type:
Article
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