The Effect of Naïve Tenofovir Dipivoxil Fumarate Monotherapy in Patients with Chronic Hepatitis B: 2-Year Results of a Real-world Single-center Study / 대한내과학회지
Korean Journal of Medicine
;
: 162-170, 2017.
Article
in Korean
| WPRIM
| ID: wpr-193487
ABSTRACT
BACKGROUND/AIMS:
An incomplete virological response has been observed to tenofovir dipivoxil fumarate (TDF) in nucleos(t)ide analogue (NA)-experienced chronic hepatitis B (CHB) patients. This study investigated the efficacy of TDF in NA-naïve CHB patients 96 weeks after treatment.METHODS:
CHB patients treated with TDF were enrolled retrospectively between November 2012 and January 2016. We assessed virological and biochemical parameters.RESULTS:
The study enrolled 179 NA-naïve patients with a median follow-up duration of 59.6 weeks. The serum hepatitis B virus (HBV) DNA level decreased significantly during treatment. The complete virological response (CVR) rate was 83.21% at week 96. In univariate analyses, the predictors of a CVR at 96 weeks were the baseline HBV DNA level (CVR vs. no-CVR, HBV DNA log10 mean value 7.34 vs. 7.86, 95% confidential interval [CI] -7.89 to -7.37; p < 0.001) and male sex (CVR vs. no-CVR, 49.1% vs. 81.3%, odds ratio [OR] 0.22, 95% CI 0.06 to 0.87; p = 0.025). In the multivariate analysis, male sex predicted a CVR at week 96. The CVR was significantly lower in males than in females (OR 0.12, 95% CI 0.02 to 0.96; p = 0.046).CONCLUSIONS:
TDF was effective for treating CHB for more than 2 years in NA-naïve patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
DNA
/
Odds Ratio
/
Hepatitis B virus
/
Multivariate Analysis
/
Retrospective Studies
/
Follow-Up Studies
/
Hepatitis B, Chronic
/
Tenofovir
/
Hepatitis B
/
Hepatitis, Chronic
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2017
Type:
Article
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