Leukotriene C4 synthase promoter polymorphism in aspirin - induced asthma / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
;
: 542-547, 1999.
Article
in Korean
| WPRIM
| ID: wpr-193530
ABSTRACT
BACKGROUND:
Aspirin/NSAIDs can release cysteinyl-leukotriene (cys-LTs) into airways and precipitate asthmatic symptoms in aspirin - induced asthma(AIA). It has been reported that there is profound overexpression of LTC4 synthase in their bronchial mucosa, compared to aspirin-tolerant asthma.Objective:
We observed whether genetic polymorphism of LTC4 synthase may be predisposed to LTC4 synthase overexpression in AIA. Subject andMETHOD:
Forty - four AIA patients having positive responses on lysin aspirin bron choprovocation tests and 47 non - aspirin induced asthma ( non - AIA ) patients having negative challenges and 32 healthy controls were enrolled. The genotypes of the promoter LTC4 synthase gene ( A,C transversion ) were determined by polymerase chain reaction and restriction fragment length polymorphism ( RFLP ) method.RESULTS:
LTC4 synthase promoter polymorphism ( A444C btransversion) was not significantly different between non - AIA and AIA patients (p>0.05). Conclusion These findings suggest that genetic polymorphism of LTC4 synthase promoter may not be predisposed to LTC, synthase overexpression in AIA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Asthma
/
Polymorphism, Restriction Fragment Length
/
Aspirin
/
Polymerase Chain Reaction
/
Leukotriene C4
/
Asthma, Aspirin-Induced
/
Genotype
/
Mucous Membrane
Limits:
Humans
Language:
Korean
Journal:
Journal of Asthma, Allergy and Clinical Immunology
Year:
1999
Type:
Article
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