Prevention and Therapeutic Strategies for Brain Injury in Extreme Prematurity / 한양의대학술지

ABSTRACT

As the evolution of neonatal intensive care has resulted in dramatic improvements in the survival of extremely preterm infants, there is major concern about the increasing rates of neurodisability among those at the limits of viability. Among the infants with parenchymal brain injury such as intraventricular hemorrhage grades III-IV, ventriculomegaly and cystic periventricular leukomalacia, more than 1 out of 3 have one of the cerebral palsy syndrome. However, research examining neuroprotection for brain injury in extremely preterm infants is limited. This review was focused on brain injury and recent strategies for neuroprotection addressing both white matter injury and gray matter dysfunction in infants born <26 weeks' gestation and/or with birth weight less than 750 g.