Loss of Integrity: Impairment of the Blood-brain Barrier in Heavy Metal-associated Ischemic Stroke
Toxicological Research
;
: 157-164, 2013.
Article
in English
| WPRIM
| ID: wpr-193679
ABSTRACT
Although stroke is one of the leading causes of death and disability worldwide, preventive or therapeutic options are still limited. Therefore, a better understanding of the pathophysiological characteristics of this life-threatening disease is urgently needed. The incidence and prevalence of ischemic stroke are increased by exposure to certain types of xenobiotics, including heavy metals, suggesting the possible toxicological contribution of these compounds to the onset or aggravation of stroke. Among the potential targets, we have focused on alterations to cerebral endothelial cells (CECs), which play important roles in maintaining the functional integrity of brain tissue.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Brain
/
Blood-Brain Barrier
/
Xenobiotics
/
Incidence
/
Prevalence
/
Cause of Death
/
Tight Junctions
/
Metals, Heavy
/
Stroke
/
Endothelial Cells
Type of study:
Incidence study
/
Prevalence study
/
Prognostic study
Language:
English
Journal:
Toxicological Research
Year:
2013
Type:
Article
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