Effects of Multiple Exposures to Pesticides on Plasma Cholinesterase Activity and p-nitrophenol Excretion in Rats / 예방의학회지
Korean Journal of Preventive Medicine
;
: 180-188, 1992.
Article
in Korean
| WPRIM
| ID: wpr-193695
ABSTRACT
The effects of multiple exposures to pesticides on plasma cholinesterase(ChE) activities and urinary p-nitrophenol excretion were evaluated in rats. Rats were received single dose i.p. with LD50/100(mg/kg) of organophosphorous(OP), organophosphorous-organochroline(OP-OC), organophosphorous-carbamate(OP-CAB), organophosphorous-organoarsenate(OP-OA) pesticides for 4 consecutive days. In repeated administration of pesticides, plasma ChE activities were decreased, but urinary p-nitrophenol were increased after the first injection and then decreased gradually. The recovery rates of ChE activities and p-nitrophenol excretion at 48 hours after the fourth infection were delayed in comparison with the baseline value of 24 hours before the first injection. Statistical significances were found between OP and other groups except OP-OA group after the second injection in plasma ChE activities, but in urinary p-nitrophenol excretion there was statistical significance only between OP and OP-CAB.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pesticides
/
Plasma
/
Cholinesterases
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Preventive Medicine
Year:
1992
Type:
Article
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